Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease that is caused by mutations in the calpain 3 gene (CAPN3), which encodes the skeletal muscle–specific calpain, calpain 3 (also known as p94). However, the precise mechanism by which p94 functions in the pathogenesis of this disease...

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Autors principals: Ojima, Koichi, Kawabata, Yukiko, Nakao, Harumi, Nakao, Kazuki, Doi, Naoko, Kitamura, Fujiko, Ono, Yasuko, Hata, Shoji, Suzuki, Hidenori, Kawahara, Hiroyuki, Bogomolovas, Julius, Witt, Christian, Ottenheijm, Coen, Labeit, Siegfried, Granzier, Henk, Toyama-Sorimachi, Noriko, Sorimachi, Michiko, Suzuki, Koichi, Maeda, Tatsuya, Abe, Keiko, Aiba, Atsu, Sorimachi, Hiroyuki
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912184/
https://ncbi.nlm.nih.gov/pubmed/20592470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40658
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