Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter

The cytokine TGF-β acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-β and use this cytokine as a potent oncogenic factor; however, the mechanistic basis for this is poorly u...

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Main Authors: Hannigan, Adèle, Smith, Paul, Kalna, Gabriela, Lo Nigro, Cristiana, Orange, Clare, O’Brien, Darren I., Shah, Reshma, Syed, Nelofer, Spender, Lindsay C., Herrera, Blanca, Thurlow, Johanna K., Lattanzio, Laura, Monteverde, Martino, Maurer, Meghan E., Buffa, Francesca M., Mann, Jelena, Chu, David C.K., West, Catharine M.L., Patridge, Max, Oien, Karin A., Cooper, Jonathan A., Frame, Margaret C., Harris, Adrian L., Hiller, Louise, Nicholson, Linda J., Gasco, Milena, Crook, Tim, Inman, Gareth J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912175/
https://ncbi.nlm.nih.gov/pubmed/20592473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36125
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