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Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle
Reengineering the receptor footprints of adeno-associated virus (AAV) isolates may yield variants with improved properties for clinical applications. We generated a panel of synthetic AAV2 vectors by replacing a hexapeptide sequence in a previously identified heparan sulfate receptor footprint with...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912150/ https://ncbi.nlm.nih.gov/pubmed/20037580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1599 |
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