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Response-adaptive Randomization for Clinical Trials with Adjustment for Covariate Imbalance
In clinical trials with a small sample size, the characteristics (covariates) of patients assigned to different treatment arms may not be well balanced. This may lead to an inflated type I error rate. This problem can be more severe in trials that use response-adaptive randomization rather than equa...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911996/ https://ncbi.nlm.nih.gov/pubmed/20658546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3978 |
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