Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

Misfolded proteins associated with diverse aggregation disorders assemble not only into a single toxic conformer but rather into a suite of aggregated conformers with unique biochemical properties and toxicities. To what extent small molecules can target and neutralize specific aggregated conformers...

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Detalhes bibliográficos
Main Authors: Ladiwala, Ali Reza A., Lin, Jason C., Bale, Shyam Sundhar, Marcelino-Cruz, Anna Marie, Bhattacharya, Moumita, Dordick, Jonathan S., Tessier, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911349/
https://ncbi.nlm.nih.gov/pubmed/20511235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.133108
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