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Barbiturates Require the N Terminus and First Transmembrane Domain of the δ Subunit for Enhancement of α1β3δ GABA(A) Receptor Currents

GABA(A) receptors are composed predominantly of αβγ receptors, which mediate primarily synaptic inhibition, and αβδ receptors, which mediate primarily extrasynaptic inhibition. At saturating GABA concentrations, the barbiturate pentobarbital substantially increased the amplitude and desensitization...

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Bibliografiske detaljer
Main Authors: Feng, Hua-Jun, Macdonald, Robert L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911329/
https://ncbi.nlm.nih.gov/pubmed/20525684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122564
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