The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination

Hyaluronan is a component of the extracellular matrix, which affects tissue homeostasis. In this study, we investigated the regulatory mechanisms of one of the hyaluronan-synthesizing enzymes, HAS2. Ectopic expression of Flag- and 6myc-HAS2 in COS-1 cells followed by immunoprecipitation and immunobl...

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Bibliographic Details
Main Authors: Karousou, Eugenia, Kamiryo, Masaru, Skandalis, Spyros S., Ruusala, Aino, Asteriou, Trias, Passi, Alberto, Yamashita, Hidetoshi, Hellman, Ulf, Heldin, Carl-Henrik, Heldin, Paraskevi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911313/
https://ncbi.nlm.nih.gov/pubmed/20507985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127050
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