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Ubiquitin Regulates GGA3-mediated Degradation of BACE1
BACE1 (β-site amyloid precursor protein-cleaving enzyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of β-amyloid, a toxic peptide that accumulates in the brain of subjects affected by Alzheimer disease. The BACE1 C-terminal fragment contains a DXXLL motif...
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| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911305/ https://ncbi.nlm.nih.gov/pubmed/20484053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092742 |
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