Mutations Altering a Structurally Conserved Loop-Helix-Loop Region of a Viral Packaging Motor Change DNA Translocation Velocity and Processivity

Many double-stranded DNA viruses employ ATP-driven motors to translocate their genomes into small, preformed viral capsids against large forces resisting confinement. Here, we show via direct single-molecule measurements that a mutation T194M downstream of the Walker B motif in the phage λ gpA packa...

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Detalhes bibliográficos
Main Authors: Tsay, James M., Sippy, Jean, delToro, Damian, Andrews, Benjamin T., Draper, Bonnie, Rao, Venigalla, Catalano, Carlos E., Feiss, Michael, Smith, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911301/
https://ncbi.nlm.nih.gov/pubmed/20525695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129395
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