Walker-A motif acts to coordinate ATP hydrolysis with motor output in viral DNA packaging

During assembly of many viruses a powerful ATP-driven motor translocates DNA into a preformed procapsid. A Walker-A “P-loop” motif is proposed to coordinate ATP binding and hydrolysis with DNA translocation. We use genetic, biochemical, and biophysical techniques to survey the roles of P-loop residu...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: delToro, Damian, Ortiz, David, Ordyan, Mariam, Sippy, Jean, Oh, Choon-Seok, Keller, Nicholas, Feiss, Michael, Catalano, Carlos E., Smith, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905814/
https://ncbi.nlm.nih.gov/pubmed/27139643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.04.029
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