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Proteolytic Processing of the γ-Subunit Is Associated with the Failure to Form GlcNAc-1-phosphotransferase Complexes and Mannose 6-Phosphate Residues on Lysosomal Enzymes in Human Macrophages
GlcNAc-1-phosphotransferase is a Golgi-resident 540-kDa complex of three subunits, α(2)β(2)γ(2), that catalyze the first step in the formation of the mannose 6-phosphate (M6P) recognition marker on lysosomal enzymes. Anti-M6P antibody analysis shows that human primary macrophages fail to generate M6...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911291/ https://ncbi.nlm.nih.gov/pubmed/20489197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129684 |
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