Proteolytic Processing of the γ-Subunit Is Associated with the Failure to Form GlcNAc-1-phosphotransferase Complexes and Mannose 6-Phosphate Residues on Lysosomal Enzymes in Human Macrophages

GlcNAc-1-phosphotransferase is a Golgi-resident 540-kDa complex of three subunits, α(2)β(2)γ(2), that catalyze the first step in the formation of the mannose 6-phosphate (M6P) recognition marker on lysosomal enzymes. Anti-M6P antibody analysis shows that human primary macrophages fail to generate M6...

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Bibliographic Details
Main Authors: Pohl, Sandra, Tiede, Stephan, Marschner, Katrin, Encarnação, Marisa, Castrichini, Monica, Kollmann, Katrin, Muschol, Nicole, Ullrich, Kurt, Müller-Loennies, Sven, Braulke, Thomas
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911291/
https://ncbi.nlm.nih.gov/pubmed/20489197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129684
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