Vasoactive Intestinal Peptide Increases Hepatic Transduction and Reduces Innate Immune Response Following Administration of Helper-dependent Ad

Helper-dependent adenoviral vectors (HDAd) are effective tools for liver-directed gene therapy because they can mediate long-term transgene expression in the absence of chronic toxicity. However, high vector doses required for efficient hepatocyte transduction by intravascular delivery result in sys...

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Detalhes bibliográficos
Main Authors: Vetrini, Francesco, Brunetti-Pierri, Nicola, Palmer, Donna J, Bertin, Terry, Grove, Nathan C, Finegold, Milton J, Ng, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911263/
https://ncbi.nlm.nih.gov/pubmed/20461064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.84
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