Disulfide-Depleted Selenoconopeptides: Simplified Oxidative Folding of Cysteine-Rich Peptides

[Image: see text] Despite the therapeutic promise of disulfide-rich, peptidic natural products, their discovery and structure/function studies have been hampered by inefficient oxidative folding methods for their synthesis. Here we report that converting the three disulfide-bridged μ-conopeptide KII...

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Hauptverfasser: Han, Tiffany S., Zhang, Min-Min, Gowd, Konkallu Hanumae, Walewska, Aleksandra, Yoshikami, Doju, Olivera, Baldomero M., Bulaj, Grzegorz
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2010
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911238/
https://ncbi.nlm.nih.gov/pubmed/20676359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml900017q
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