T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

OBJECTIVE: Insulin-induced phosphatidylinositol 3-kinase (PI3K)/Akt signaling and interleukin-6 (IL-6)-instigated JAK/STAT3-signaling pathways in the liver inhibit the expression of gluconeogenic genes to decrease hepatic glucose output. The insulin receptor (IR) and JAK1 tyrosine kinases and STAT3...

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Main Authors: Fukushima, Atsushi, Loh, Kim, Galic, Sandra, Fam, Barbara, Shields, Ben, Wiede, Florian, Tremblay, Michel L., Watt, Matthew J., Andrikopoulos, Sofianos, Tiganis, Tony
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911070/
https://ncbi.nlm.nih.gov/pubmed/20484139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1365
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