Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2

Hepatic insulin resistance is a key contributor to the pathogenesis of obesity and type 2 diabetes (T2D). Paradoxically the development of insulin resistance in the liver is not universal, but pathway-selective, such that insulin fails to suppress gluconeogenesis but promotes lipogenesis, contributi...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Gurzov, Esteban N., Tran, Melanie, Fernandez-Rojo, Manuel A, Merry, Troy L, Zhang, Xinmei, Xu, Yang, Fukushima, Atsushi, Waters, Michael J, Watt, Matthew J, Andrikopoulos, Sofianos, Neel, Benjamin G, Tiganis, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335267/
https://ncbi.nlm.nih.gov/pubmed/24954415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.05.011
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