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Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2
Hepatic insulin resistance is a key contributor to the pathogenesis of obesity and type 2 diabetes (T2D). Paradoxically the development of insulin resistance in the liver is not universal, but pathway-selective, such that insulin fails to suppress gluconeogenesis but promotes lipogenesis, contributi...
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| Udgivet i: | Cell Metab |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4335267/ https://ncbi.nlm.nih.gov/pubmed/24954415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.05.011 |
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