Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

OBJECTIVE: Previous studies showed that genetic deletion or pharmacological blockade of the receptor for advanced glycation end products (RAGE) prevents the early structural changes in the glomerulus associated with diabetic nephropathy. To overcome limitations of mouse models that lack the progress...

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Bibliographische Detailangaben
Hauptverfasser: Reiniger, Nina, Lau, Kai, McCalla, Daren, Eby, Bonnie, Cheng, Bin, Lu, Yan, Qu, Wu, Quadri, Nosirudeen, Ananthakrishnan, Radha, Furmansky, Maryana, Rosario, Rosa, Song, Fei, Rai, Vivek, Weinberg, Alan, Friedman, Richard, Ramasamy, Ravichandran, D'Agati, Vivette, Schmidt, Ann Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2010
Schlagworte:
Complications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911065/
https://ncbi.nlm.nih.gov/pubmed/20627935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1766
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