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PARP inhibition: PARP1 and beyond
Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910902/ https://ncbi.nlm.nih.gov/pubmed/20200537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2812 |
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