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AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2(V617F)-independent overexpression of NF-E2
The transcription factor NF-E2 is overexpressed in the majority of patients with polycythemia vera (PV). Concomitantly, 95% of these patients carry the JAK2(V617F) mutation. Although NF-E2 levels correlate with JAK2(V671F) allele burden in some PV cohorts, the molecular mechanism causing aberrant NF...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910609/ https://ncbi.nlm.nih.gov/pubmed/20339092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-254664 |
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