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AN APOLIPOPROTEIN E4 FRAGMENT CAN PROMOTE INTRACELLULAR ACCUMULATION OF AMYLOID PEPTIDE BETA 42
Apolipoprotein E (apoE) plays a crucial role in lipid transport in circulation and the brain. The apoE4 isoform is a major risk factor for Alzheimer's disease (AD). ApoE4 is more susceptible to proteolysis than other apoE isoforms and apoE4 fragments have been found in brains of AD patients. Th...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910182/ https://ncbi.nlm.nih.gov/pubmed/20412390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06756.x |
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