AN APOLIPOPROTEIN E4 FRAGMENT CAN PROMOTE INTRACELLULAR ACCUMULATION OF AMYLOID PEPTIDE BETA 42

Apolipoprotein E (apoE) plays a crucial role in lipid transport in circulation and the brain. The apoE4 isoform is a major risk factor for Alzheimer's disease (AD). ApoE4 is more susceptible to proteolysis than other apoE isoforms and apoE4 fragments have been found in brains of AD patients. Th...

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Hlavní autoři: Dafnis, Ioannis, Stratikos, Efstratios, Tzinia, Athina, Tsilibary, Effie C., Zannis, Vassilis I., Chroni, Angeliki
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910182/
https://ncbi.nlm.nih.gov/pubmed/20412390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06756.x
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