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Identification of the 6-Sulfate Binding Site Unique to α-Subunit-Containing Isozymes of Human β-Hexosaminidase
In humans, β-hexosaminidase A (αβ) is required to hydrolyze GM2 ganglioside. A deficiency of either the α- or β-subunit leads to a severe neurological disease, Tay-Sachs or Sandhoff disease, respectively. In mammals β-hexosaminidase B (ββ) and S (αα) are other major and minor isozymes. The primary s...
में बचाया:
| मुख्य लेखकों: | , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2001
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910086/ https://ncbi.nlm.nih.gov/pubmed/11331008 |
| टैग : |
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