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Identification of the 6-Sulfate Binding Site Unique to α-Subunit-Containing Isozymes of Human β-Hexosaminidase

In humans, β-hexosaminidase A (αβ) is required to hydrolyze GM2 ganglioside. A deficiency of either the α- or β-subunit leads to a severe neurological disease, Tay-Sachs or Sandhoff disease, respectively. In mammals β-hexosaminidase B (ββ) and S (αα) are other major and minor isozymes. The primary s...

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Bibliografiske detaljer
Main Authors: Sharma, Rohita, Deng, Huinan, Leung, Amy, Mahuran, Don
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910086/
https://ncbi.nlm.nih.gov/pubmed/11331008
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