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An α-subunit loop structure is required for GM2 activator protein binding by β-hexosaminidase A

The α- and/or β-subunits of human β-hexosaminidase A (αβ) and B (ββ) are ~60% identical. In vivo only β-hexosaminidase A can utilize GM2 ganglioside as a substrate, but requires the GM2 activator protein to bind GM2 ganglioside and then interact with the enzyme, placing the terminal GalNAc residue i...

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Bibliografiske detaljer
Main Authors: Zarghooni, Maryam, Bukovac, Scott, Tropak, Michael, Callahan, John, Mahuran, Don
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918538/
https://ncbi.nlm.nih.gov/pubmed/15485660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2004.09.159
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