Targeting of 5-aza-2′-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme

5-Aza-2′-deoxycytidine (5-aza-dC) is a nucleoside analogue with cytotoxic and DNA demethylating effects. Here we show that 5-aza-dC induces the proteasomal degradation of free (non-chromatin bound) DNMT1 through a mechanism which is dependent on DNA synthesis and the targeting of incorporated 5-aza-...

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Bibliografiske detaljer
Main Authors: Patel, Katan, Dickson, Jacqueline, Din, Shahida, Macleod, Kenneth, Jodrell, Duncan, Ramsahoye, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Gene Regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910061/
https://ncbi.nlm.nih.gov/pubmed/20348135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq187
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