Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

We report that combining a DNA analog (2′F-ANA) with rigid RNA analogs [2′F-RNA and/or locked nucleic acid (LNA)] in siRNA duplexes can produce gene silencing agents with enhanced potency. The favored conformations of these two analogs are different, and combining them in a 1–1 pattern led to reduce...

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Main Authors: Deleavey, Glen F., Watts, Jonathan K., Alain, Tommy, Robert, Francis, Kalota, Anna, Aishwarya, Veenu, Pelletier, Jerry, Gewirtz, Alan M., Sonenberg, Nahum, Damha, Masad J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Synthetic Biology and Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910058/
https://ncbi.nlm.nih.gov/pubmed/20413581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq181
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