Transgenic Mice Expressing Constitutively Active Akt in Oral Epithelium Validate Klf4 as a Potential Biomarker of Head and Neck Squamous Cell Carcinoma

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a common human neoplasia, of poor prognosis and survival, which frequently displays Akt overactivation. Previously, we reported that mice expressing high levels of constitutively Akt activity (myrAkt) in oral epithelia develop lesions and...

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Hauptverfasser: Moral, Marta, Segrelles, Carmen, Martínez-Cruz, Ana Belén, Lorz, Corina, Santos, Mirentxu, García-Escudero, Ramón, Lu, Jerry, Buitrago, Agueda, Costa, Clotilde, Saiz, Cristina, Ariza, José M., Dueñas, Marta, Rodriguez-Peralto, Jose L, Martinez-Tello, Francisco J, Rodriguez-Pinilla, Maria, Sanchez-Cespedes, Montserrat, DiGiovanni, John, Paramio, Jesús M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909848/
https://ncbi.nlm.nih.gov/pubmed/19779097
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