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The use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction
Anti-neutrophil cytoplasmic antibodies (ANCA) to proteinase 3 (PR3) are found in patients with small-vessel vasculitis. PR3-ANCA bind strongly to membrane PR3 (mPR3) that is presented by the NB1 receptor. We performed high-throughput screening using a small molecule library to identify compounds tha...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Science Inc
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909422/ https://ncbi.nlm.nih.gov/pubmed/20456416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04174.x |
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