The use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction

Anti-neutrophil cytoplasmic antibodies (ANCA) to proteinase 3 (PR3) are found in patients with small-vessel vasculitis. PR3-ANCA bind strongly to membrane PR3 (mPR3) that is presented by the NB1 receptor. We performed high-throughput screening using a small molecule library to identify compounds tha...

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Detalhes bibliográficos
Main Authors: Choi, M, Eulenberg, C, Rolle, S, von Kries, J P, Luft, F C, Kettritz, R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909422/
https://ncbi.nlm.nih.gov/pubmed/20456416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04174.x
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