Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase

5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP, is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. We studied the effects of AICAR on the growth of retinoblastoma cell lines (Y79, WERI, and RB143)....

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Главные авторы: Theodoropoulou, Sofia, Kolovou, Paraskevi E., Morizane, Yuki, Kayama, Maki, Nicolaou, Fotini, Miller, Joan W., Gragoudas, Evangelos, Ksander, Bruce R., Vavvas, Demetrios G.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2010
Предметы:
Research Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909289/
https://ncbi.nlm.nih.gov/pubmed/20371623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-152546
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