New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells

Medulloblastoma is the most common malignant brain tumor in children, and despite improvements in the overall survival rate, it still lacks an effective treatment. Src plays an important role in cancer, and recently high Src activity was documented in medulloblastoma. In this report, we examined the...

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Main Authors: Rossi, Alessandra, Schenone, Silvia, Angelucci, Adriano, Cozzi, Martina, Caracciolo, Valentina, Pentimalli, Francesca, Puca, Andrew, Pucci, Biagio, La Montagna, Raffaele, Bologna, Mauro, Botta, Maurizio, Giordano, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2010
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909284/
https://ncbi.nlm.nih.gov/pubmed/20354138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-148593
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