Restoration of domain folding and interdomain assembly by second-site suppressors of the ΔF508 mutation in CFTR

Deletion of PHE508 (ΔF508) from the first nucleotide-binding domain (NBD1) of CFTR, which causes most cystic fibrosis, disrupts the folding and assembly of the protein. Although the folding pathways and yield of isolated NBD1 are altered, its global structure is not, and details of the changes in th...

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Bibliographic Details
Main Authors: He, Lihua, Aleksandrov, Luba A., Cui, Liying, Jensen, Timothy J., Nesbitt, Kenneth L., Riordan, John R.
Format: Artigo
Language:Inglês
Published: The Federation of American Societies for Experimental Biology 2010
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909275/
https://ncbi.nlm.nih.gov/pubmed/20233947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-141788
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