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Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca(2+) leak and disturbs Ca(2+) signalling
BACKGROUND INFORMATION: The IP(3)R (inositol 1,4,5-trisphosphate receptor) is a tetrameric channel that accounts for a large part of the intracellular Ca(2+) release in virtually all cell types. We have previously demonstrated that caspase-3-mediated cleavage of IP(3)R1 during cell death generates a...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909191/ https://ncbi.nlm.nih.gov/pubmed/17868032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BC20070086 |
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