Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca(2+) leak and disturbs Ca(2+) signalling

BACKGROUND INFORMATION: The IP(3)R (inositol 1,4,5-trisphosphate receptor) is a tetrameric channel that accounts for a large part of the intracellular Ca(2+) release in virtually all cell types. We have previously demonstrated that caspase-3-mediated cleavage of IP(3)R1 during cell death generates a...

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Main Authors: Verbert, Leen, Lee, Bora, Kocks, Sarah L., Assefa, Zerihun, Parys, Jan B., Missiaen, Ludwig, Callewaert, Geert, Fissore, Rafael A., De Smedt, Humbert, Bultynck, Geert
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909191/
https://ncbi.nlm.nih.gov/pubmed/17868032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BC20070086
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