Polycystin-2 Activation by Inositol 1,4,5-Trisphosphate-induced Ca(2+) Release Requires Its Direct Association with the Inositol 1,4,5-Trisphosphate Receptor in a Signaling Microdomain

Autosomal dominant polycystic kidney disease is characterized by the loss-of-function of a signaling complex involving polycystin-1 and polycystin-2 (TRPP2, an ion channel of the TRP superfamily), resulting in a disturbance in intracellular Ca(2+) signaling. Here, we identified the molecular determi...

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Main Authors: Sammels, Eva, Devogelaere, Benoit, Mekahli, Djalila, Bultynck, Geert, Missiaen, Ludwig, Parys, Jan B., Cai, Yiqiang, Somlo, Stefan, De Smedt, Humbert
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881802/
https://ncbi.nlm.nih.gov/pubmed/20375013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090662
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