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An unfolded C(H)1 domain controls the assembly and secretion of IgG antibodies
A prerequisite for antibody secretion and function is the assembly into a defined quaternary structure, composed of two heavy and two light chains for IgG. Unassembled heavy chains are actively retained in the endoplasmic reticulum (ER) until they associate with light chains. Our mechanistic analysi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908990/ https://ncbi.nlm.nih.gov/pubmed/19524537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.028 |
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