The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that rely on antibodies as part of their adaptive immune system. They produce the immunoglobulin new antigen receptor (IgNAR), a homodimeric heavy chain-only antibody, as a major part of their humoral adaptive immun...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Feige, Matthias J., Gräwert, Melissa A., Marcinowski, Moritz, Hennig, Janosch, Behnke, Julia, Ausländer, David, Herold, Eva M., Peschek, Jirka, Castro, Caitlin D., Flajnik, Martin, Hendershot, Linda M., Sattler, Michael, Groll, Michael, Buchner, Johannes
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050542/
https://ncbi.nlm.nih.gov/pubmed/24830426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321502111
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