The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that rely on antibodies as part of their adaptive immune system. They produce the immunoglobulin new antigen receptor (IgNAR), a homodimeric heavy chain-only antibody, as a major part of their humoral adaptive immun...

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Bibliographic Details
Main Authors: Feige, Matthias J., Gräwert, Melissa A., Marcinowski, Moritz, Hennig, Janosch, Behnke, Julia, Ausländer, David, Herold, Eva M., Peschek, Jirka, Castro, Caitlin D., Flajnik, Martin, Hendershot, Linda M., Sattler, Michael, Groll, Michael, Buchner, Johannes
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050542/
https://ncbi.nlm.nih.gov/pubmed/24830426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321502111
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