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The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins
Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that rely on antibodies as part of their adaptive immune system. They produce the immunoglobulin new antigen receptor (IgNAR), a homodimeric heavy chain-only antibody, as a major part of their humoral adaptive immun...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4050542/ https://ncbi.nlm.nih.gov/pubmed/24830426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321502111 |
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