The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that rely on antibodies as part of their adaptive immune system. They produce the immunoglobulin new antigen receptor (IgNAR), a homodimeric heavy chain-only antibody, as a major part of their humoral adaptive immun...

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Detalhes bibliográficos
Main Authors: Feige, Matthias J., Gräwert, Melissa A., Marcinowski, Moritz, Hennig, Janosch, Behnke, Julia, Ausländer, David, Herold, Eva M., Peschek, Jirka, Castro, Caitlin D., Flajnik, Martin, Hendershot, Linda M., Sattler, Michael, Groll, Michael, Buchner, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050542/
https://ncbi.nlm.nih.gov/pubmed/24830426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321502111
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