High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

IgM is the first antibody produced during the humoral immune response. Despite its fundamental role in the immune system, IgM is structurally only poorly described. In this work we used X-ray crystallography and NMR spectroscopy to determine the atomic structures of the constant IgM Fc domains (Cµ2,...

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Bibliografische gegevens
Hoofdauteurs: Müller, Roger, Gräwert, Melissa A., Kern, Thomas, Madl, Tobias, Peschek, Jirka, Sattler, Michael, Groll, Michael, Buchner, Johannes
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690842/
https://ncbi.nlm.nih.gov/pubmed/23733956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300547110
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