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Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation

Efavirenz primary and secondary metabolism was investigated in vitro and in vivo. In human liver microsome (HLM) samples, 7- and 8-hydroxyefavirenz accounted for 22.5 and 77.5% of the overall efavirenz metabolism, respectively. Kinetic, inhibition, and correlation analyses in HLM samples and experim...

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Bibliografiset tiedot
Päätekijät: Ogburn, Evan T., Jones, David R., Masters, Andrea R., Xu, Cong, Guo, Yingying, Desta, Zeruesenay
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908985/
https://ncbi.nlm.nih.gov/pubmed/20335270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.031393
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