NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features

Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrP(C)) conformer, denoted as infectious scrapie isoform or PrP(Sc). In inherited human prion diseases, mutations in the open reading frame of the PrP gene (PRNP) are hypo...

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Détails bibliographiques
Auteurs principaux: Ilc, Gregor, Giachin, Gabriele, Jaremko, Mariusz, Jaremko, Łukasz, Benetti, Federico, Plavec, Janez, Zhukov, Igor, Legname, Giuseppe
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908606/
https://ncbi.nlm.nih.gov/pubmed/20661422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011715
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