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NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features
Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrP(C)) conformer, denoted as infectious scrapie isoform or PrP(Sc). In inherited human prion diseases, mutations in the open reading frame of the PrP gene (PRNP) are hypo...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908606/ https://ncbi.nlm.nih.gov/pubmed/20661422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011715 |
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