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Potent and Selective Inhibition of the Open-Channel Conformation of AMPA Receptors by an RNA Aptamer

Inhibitors of AMPA receptors are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Here we report the identification of an RNA inhibitor or aptamer by an in vitro evolution approach. Using a laser-pulse photolysis...

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Detalhes bibliográficos
Main Authors: Huang, Zhen, Han, Yan, Wang, Congzhou, Niu, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908592/
https://ncbi.nlm.nih.gov/pubmed/20518485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100690k
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