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Potent and Selective Inhibition of a Single α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit by an RNA Aptamer

Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Here, we describe the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and a chara...

詳細記述

保存先:
書誌詳細
主要な著者: Park, Jae-Seon, Wang, Congzhou, Han, Yan, Huang, Zhen, Niu, Li
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
RNA
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083151/
https://ncbi.nlm.nih.gov/pubmed/21402710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229559
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