One aptamer, two functions: the full-length aptamer inhibits AMPA receptors, while the short one inhibits both AMPA and kainate receptors

AMPA and kainate receptors, along with NMDA receptors, are distinct subtypes of glutamate ion channels. Excessive activity of AMPA and kainate receptors has been implicated in neurological diseases, such as epilepsy and neuropathic pain. Antagonists that block their activities are therefore potentia...

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Bibliographic Details
Published in:RNA Dis
Main Authors: Jaremko, William J., Huang, Zhen, Wen, Wei, Wu, Andrew, Karl, Nicholas, Niu, Li
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553901/
https://ncbi.nlm.nih.gov/pubmed/28804757
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