Structure of the MLL CXXC domain – DNA complex and its functional role in MLL-AF9 leukemia

MLL (Mixed Lineage Leukemia) is the target of chromosomal translocations which cause leukemias with poor prognosis. All leukemogenic MLL fusion proteins retain the CXXC domain which binds to nonmethylated CpG DNA. We present the solution structure of the MLL CXXC domain in complex with DNA, showing...

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Main Authors: Cierpicki, Tomasz, Risner, Laurie E., Grembecka, Jolanta, Lukasik, Stephen M., Popovic, Relja, Omonkowska, Monika, Shultis, David S., Zeleznik-Le, Nancy J., Bushweller, John H.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908503/
https://ncbi.nlm.nih.gov/pubmed/20010842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1714
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