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The X-Ray Structure of Carboxypeptidase A Inhibited by a Thiirane Mechanism-Based Inhibitor

The three-dimensional X-ray crystal structure of carboxypeptidase A, a zinc-dependent hydrolase, covalently modified by a mechanism-based thiirane inactivator, 2-benzyl-3,4-epithiobutanoic acid, has been solved to 1.38 Å resolution. The interaction of the thiirane moiety of the inhibitor with the ac...

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Detalhes bibliográficos
Main Authors: Fernández, Daniel, Testero, Sebastian, Vendrell, Josep, Avilés, Francesc X., Mobashery, Shahriar
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908478/
https://ncbi.nlm.nih.gov/pubmed/19895506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00907.x
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