Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library

[Image: see text] Metallocarboxypeptidases (MCPs) are involved in many biological processes such as fibrinolysis or inflammation, development, Alzheimer’s disease, and various types of cancer. We describe the synthesis and kinetic characterization of a focused library of 22 thiirane- and oxirane-bas...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Testero, Sebastián A., Granados, Carla, Fernández, Daniel, Gallego, Pablo, Covaleda, Giovanni, Reverter, David, Vendrell, Josep, Avilés, Francesc X., Pallarès, Irantzu, Mobashery, Shahriar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2017
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641956/
https://ncbi.nlm.nih.gov/pubmed/29057062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00346
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