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Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A
A high-resolution carboxypeptidase-Zn(2+)-citrate complex was studied by X-ray diffraction and enzyme kinetics for the first time. The citrate molecule acts as a competitive inhibitor of this benchmark zinc-dependent peptidase, chelating the catalytic zinc ion in the active site of the enzyme and in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE-Hindawi Access to Research
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3144702/ https://ncbi.nlm.nih.gov/pubmed/21804935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/128676 |
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