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Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A

A high-resolution carboxypeptidase-Zn(2+)-citrate complex was studied by X-ray diffraction and enzyme kinetics for the first time. The citrate molecule acts as a competitive inhibitor of this benchmark zinc-dependent peptidase, chelating the catalytic zinc ion in the active site of the enzyme and in...

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Bibliografiske detaljer
Main Authors: Fernández, Daniel, Boix, Ester, Pallarès, Irantzu, Avilés, Francesc X., Vendrell, Josep
Format: Artigo
Sprog:Inglês
Udgivet: SAGE-Hindawi Access to Research 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144702/
https://ncbi.nlm.nih.gov/pubmed/21804935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/128676
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