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Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and FLIP Inhibition
The death inducing signaling complex (DISC) comprising Fas, FADD and caspase-8/10 is assembled via homotypic associations between death domains (DDs) of Fas and FADD and between death effector domains (DEDs) of FADD and caspase-8/10. Caspase-8/10 and FLICE/caspase-8 inhibitory proteins (FLIPs) that...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908330/ https://ncbi.nlm.nih.gov/pubmed/16364918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2005.10.023 |
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